{"product_id":"abm160045","title":"E2F-2 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eE2F transcription factor 2 encoded by E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660468658516,"sku":"ABM160045","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660468691284,"sku":"ABM160046","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660468724052,"sku":"ABM160047","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1cec699f3d50b86e09a9c0d8418462da2591bdd4876fbf6ca0cbe14ae565f8af.jpg?v=1792157378","url":"https:\/\/www.abmium.com\/products\/abm160045","provider":"ABMIUM","version":"1.0","type":"link"}