{"product_id":"abm158623","title":"CUL-2 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1\/CUL-1\/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex. CUL-5, also designated vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cullin family as it shares substantial sequence homology with CUL-1.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660452897108,"sku":"ABM158623","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660452929876,"sku":"ABM158624","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660452962644,"sku":"ABM158625","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-bb08e0a2de42d237d5a54f28914e33a37e4b3d90b7e25473838e6c8da128dfcc.jpg?v=1792157314","url":"https:\/\/www.abmium.com\/products\/abm158623","provider":"ABMIUM","version":"1.0","type":"link"}