{"product_id":"abm154077","title":"BID (Cleaved-Arg71) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eIntact BH3 motif is required by BIK| BID| BAK| BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1| isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.|PTM:Phosphorylated upon DNA damage| probably by ATM or ATR.|PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.|subcellular location:A significant proportion of isoform 2 localizes to mitochondria| it may be cleaved constitutively.|subcellular location:Associated with the mitochondrial membrane.|subcellular location:Translocates to mitochondria as an integral membrane protein.|subcellular location:When uncleaved| it is predominantly cytoplasmic.|subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.|tissue specificity:Isoforms 2 and 3 are expressed in spleen| bone marrow| cerebral and cerebellar cortex. Isoform 2 is expressed in spleen| pancreas and placenta (at protein level). Isoform 3 is expressed in lung| pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660677423444,"sku":"ABM154077","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660677456212,"sku":"ABM154078","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660677488980,"sku":"ABM154079","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/products\/abm154077","provider":"ABMIUM","version":"1.0","type":"link"}