UniProt and IntAct report interaction with renin, which proteolytically processes angiotensinogen in the renin-angiotensin system.
ABMIUM target intelligence
angiotensinogen
Angiotensinogen (AGT), also known as serpin A8/SERPINA8, is the precursor protein of angiotensin peptides in the renin-angiotensin system. This ABMIUM record connects NCBI Gene 183 and UniProtKB P01019 to catalogue-backed research products.
Read full target overviewABMIUM research catalogue
Loading products for AGT…
Names used across publications, databases and supplier catalogues.
Angiotensinogen (AGT) is an essential precursor in the renin-angiotensin system. Renin cleavage generates angiotensin I, which is further processed to bioactive angiotensin peptides including angiotensin II, supporting regulation of blood pressure, vascular tone, body-fluid balance and electrolyte homeostasis.
Angiotensinogen/AGT is studied in the renin-angiotensin system, cardiovascular biology, blood-pressure regulation, renal physiology and fluid/electrolyte homeostasis. Review the linked ABMIUM research products and confirm species, sample type, application, assay format and product-level validation before use.
Interaction context
Explore biologically relevant proteins connected to AGT through receptor complexes, pathway context, curated molecular relationships or database-supported functional evidence. Each relationship should be interpreted independently and does not establish reagent suitability.
UniProt and IntAct report interaction with renin, which proteolytically processes angiotensinogen in the renin-angiotensin system.
UniProt reports angiotensin II derived from AGT as a ligand for AGTR1.
UniProt reports angiotensin II derived from AGT as a ligand for AGTR2.
Interpretation: Identity, aliases and biological context were checked against NCBI Gene 183 and reviewed UniProtKB P01019 on 2026-08-17. Catalogue association does not establish suitability for a specific experiment; confirm product-level validation and sample compatibility.