ABMIUM target intelligence
anterior gradient 2, protein disulphide isomerase family member
AGR2 (anterior gradient 2, protein disulphide isomerase family member; PDIA17) is an endoplasmic-reticulum protein of the protein-disulfide-isomerase family. It is studied in protein folding, epithelial secretory biology, mucin production and ER proteostasis.
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Names used across publications, databases and supplier catalogues.
AGR2 is an ER-localized protein-disulfide-isomerase-family molecular chaperone with a thioredoxin-like catalytic domain. NCBI describes roles in protein folding and thiol-disulfide interchange, while reviewed UniProt supports a requirement for MUC2 synthesis and secretion and a role in intestinal mucus production.
AGR2 is used to investigate ER protein quality control, epithelial secretory pathways, mucin biogenesis and cellular responses to high secretory demand. Experimental interpretation benefits from distinguishing intracellular ER-localized AGR2 from extracellular AGR2 reported in some biological contexts.