{"product_id":"mouse-endostatin-elisa-kit-picokine-ek1376","title":"Mouse Endostatin ELISA Kit PicoKine®","description":"\u003cp\u003eMouse Endostatin ELISA Kit PicoKine® is a research-use ELISA kit from Boster Bio for measuring Collagen alpha-1 in Cell culture supernatant, Cell lysates, serum and plasma (heparin, EDTA). samples from Mouse. Use the listed assay range, sample guidance and protocol documents to assess suitability for the intended study.\u003c\/p\u003e\nMouse Endostatin ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Col18a1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg\/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.\u003cp\u003eEndostatin is a naturally-occurring 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e","brand":"Boster Bio","offers":[{"title":"96 wells\/kit, with removable strips.","offer_id":56042457727316,"sku":"ABM32961","price":442.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ek1376.png?v=1781655975","url":"https:\/\/www.abmium.com\/ja\/products\/mouse-endostatin-elisa-kit-picokine-ek1376","provider":"ABMIUM","version":"1.0","type":"link"}