{"product_id":"elk-es2661-jmy-rabbit-pab","title":"JMY rabbit pAb","description":"\u003cp\u003eJMY rabbit pAb is a research-use antibody from ELK Biotechnology for studying JMY in WB, IHC, ELISA workflows with listed reactivity for Human, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003efunction:Cofactor that increases p53\/TP53 response via its interaction with p300\/EP300. Increases p53\/TP53-dependent transcription and apoptosis, suggesting an important role in p53\/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300\/EP300 and its function in p53\/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300\/EP300, the complex being recruited to activated p53\/TP53. Interacts with TTC5.,\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eJMY Polyclonal Antibody detects endogenous levels of JMY protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using JMY Polyclonal Antibody | Western blot analysis of lysates from COLO cells, using JMY Antibody. The lane on the right is blocked with the synthesized peptide. | Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186191380820,"sku":"ABM107199","price":220.0,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186191413588,"sku":"ABM97335","price":132.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES2661-c-1.jpg?v=1782043712","url":"https:\/\/www.abmium.com\/ja\/products\/elk-es2661-jmy-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}