ABMIUM target intelligence
BAG cochaperone 2
BAG cochaperone 2 (BAG2), also called BAG family molecular chaperone regulator 2, is an HSP70/HSC70 co-chaperone that regulates the chaperone ATPase cycle. This target page groups ABMIUM catalogue reagents for studying BAG2-dependent chaperone control, proteostasis and cellular stress responses.
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Names used across publications, databases and supplier catalogues.
BAG2 contains a BAG domain that binds HSP70-family chaperones and functions as a nucleotide-exchange factor, promoting ADP release during the HSP70/HSC70 chaperone cycle. Through this activity, BAG2 influences client-protein handling, folding and protein quality-control processes.
BAG2 is studied in HSP70/HSC70 chaperone regulation, proteostasis, stress responses and protein quality control. Experimental work can assess BAG2 abundance, chaperone association and changes in client-protein handling under basal or proteotoxic-stress conditions.