{"product_id":"tribio-wnt-c59-porcupine-inhibitor","title":"Wnt-C59, Porcupine inhibitor","description":"\u003cp\u003eWnt-C59 is a potent (IC50 = 74 pmol\/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice. Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+\/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411079864660,"sku":"ABM148954-1","price":245.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411079897428,"sku":"ABM148954-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4605.png?v=1791105159","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-wnt-c59-porcupine-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}