{"product_id":"tribio-verteporfin-yap-inhibitor-anticancer-activity","title":"Verteporfin, YAP inhibitor; Anticancer activity","description":"\u003cp\u003ePhotosensitive drug used to ablate unwanted neovasculature in the eye, esophageal mucosa, and elsewhere using light to create damaging free radicals and high-molecular-weight crosslinked oligomers. Independent of light exposure, verteporfin inhibits transcription by YAP\/TAZ (via disruption of YAP-TEAD interaction)(IC50 = 2.5 µM), inhibiting autophagy and halting proliferation of cancer and cancer stem cell lines. Inhibits autophagosome formation. Reverses differentiation of Src-overexpressing embryonic stem cells, and blocks SARS-CoV-2 infection in vitro and in vivo\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411090121044,"sku":"ABM148933-1","price":490.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411090153812,"sku":"ABM148933-2","price":123.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3487.png?v=1791105181","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-verteporfin-yap-inhibitor-anticancer-activity","provider":"ABMIUM","version":"1.0","type":"link"}