{"product_id":"tribio-splitomicin-sirt1-inhibitor","title":"Splitomicin, SIRT1 inhibitor","description":"\u003cp\u003eSplitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA. Splitomycin inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome. Reverses ischemic preconditioning-induced cardioprotection in a mouse model\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411081240916,"sku":"ABM148766-1","price":360.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411081273684,"sku":"ABM148766-2","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2615.png?v=1791105162","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-splitomicin-sirt1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}