{"product_id":"tribio-sgc-gak-1-cyclin-g-associated-kinase-gak-inhibitor","title":"SGC-GAK-1, Cyclin G Associated Kinase (GAK) inhibitor","description":"\u003cp\u003eVery potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis: KD = 1.9 nM with \u0026gt;50-fold selectivity against a panel of 400 kinases. Also displays affinity for RIPK2 (KD = 110 nM) and ADCK3 (KD = 190 nM). Has potent cellular activity in HEK293T cells (IC50 = 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50 = 0.65 µM) and 22Rv1 (IC50 = 0.17 µM)\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57411064168788,"sku":"ABM148728-1","price":90.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57411064201556,"sku":"ABM148728-2","price":319.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4796.png?v=1791104990","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-sgc-gak-1-cyclin-g-associated-kinase-gak-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}