{"product_id":"tribio-s1ra-selective-sigma-1-antagonist","title":"S1RA, Selective sigma-1 antagonist","description":"\u003cp\u003eS1RA (E-52862) is a potent and selective σ1 antagonist with weak binding at σ2 (IC50’s: σ1 = 17nM, σ2 = 9300nM). S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner. BD1063 potentiated µ-opioid antinociception in mice in a σ-dependent manner. S1RA displayed neuroprotective effects in a mouse model of ischemic stroke\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411065938260,"sku":"ABM148692-1","price":490.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411065971028,"sku":"ABM148692-2","price":139.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4201.png?v=1791104993","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-s1ra-selective-sigma-1-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}