{"product_id":"tribio-rita-p53-mdm2-interaction-inhibitor","title":"RITA, p53-MDM2 interaction inhibitor","description":"\u003cp\u003eRITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 and preventing its proteasomal degradation. It also weakly (computed Kd = 22 µM) binds HDM2 in the cleft that contacts the p53 transactivation domain. Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK\/SAPK\/p38; protein translation) pathways. Induces senescence in head and neck cancer cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411056730452,"sku":"ABM148661-1","price":490.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411056763220,"sku":"ABM148661-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3385.png?v=1791104970","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-rita-p53-mdm2-interaction-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}