{"product_id":"tribio-ml382-mrgprx1-positive-allosteric-modulator","title":"ML382, MRGPRX1 positive allosteric modulator","description":"\u003cp\u003eML382 is a potent (EC 50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons. ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410939683156,"sku":"ABM147366-1","price":154.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410939715924,"sku":"ABM147366-2","price":545.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3937.png?v=1791103996","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-ml382-mrgprx1-positive-allosteric-modulator","provider":"ABMIUM","version":"1.0","type":"link"}