{"product_id":"tribio-lapachone-topoisomerase-i-inhibitor","title":"ß-Lapachone, Topoisomerase I inhibitor","description":"\u003cp\u003eA naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action. Induces apoptosis in a number of cancer cell lines. In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms resulting in the production of reactive oxygen species. Suppresses radiation-induced activation of NFκB\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411065348436,"sku":"ABM148690-1","price":327.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411065381204,"sku":"ABM148690-2","price":85.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2386.png?v=1791104992","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-lapachone-topoisomerase-i-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}