{"product_id":"tribio-kc7f2-hif-1a-inhibitor","title":"KC7F2, HIF-1a Inhibitor","description":"\u003cp\u003eInhibits HIF-1α (IC50 = 20 µM in a HIF-reporter cell line). It suppresses mTORC1 phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K), thereby down-regulating translation of HIF-1α transcripts into protein1. It shows marked dose-response cytotoxicity (IC50 = 15 – 25 µM) in cancer cell lines such as MCF7 and A5491. Decreases viability of epidermal stem cells in a wound healing model. Treatment with 10 μM KC7F2 significantly reduced NKCC1, but not NFAT5, expression in hippocampal neurons in a model of hypoxia-ischemia\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410916745556,"sku":"ABM147229-1","price":98.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410916778324,"sku":"ABM147229-2","price":384.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4714.png?v=1791103632","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-kc7f2-hif-1a-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}