{"product_id":"tribio-jte-607-mrna-processing-inhibitor","title":"JTE-607, mRNA processing inhibitor","description":"\u003cp\u003eInhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC’s) without causing immunosuppression: IC50’s = 11 nM (TNF-α), 5.9 nM (IL-1β), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10). It displayed efficacy in a mouse model of septic shock. JTE-607 also showed inhibitory activity against acute myelogenous leukemia cell lines. Recently, the mechanism of action of JTE-607 (a pro-drug, with the active species being the free acid) has been found to be inhibition of pre-messenger RNA endonuclease Cleavage and Polyadenylation Specificity Factor 3 (CPSF3). This prevents release of newly synthesized mRNA’s resulting in read-through transcription and the formation of DNA-RNA hybrid R-loop structures. Transcripts down-regulated by JTE-607 were related to DNA damage-based phenotype\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410913567060,"sku":"ABM147220-1","price":450.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410913599828,"sku":"ABM147220-2","price":131.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4842.png?v=1791103624","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-jte-607-mrna-processing-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}