{"product_id":"tribio-ipi-549-selective-pi3k","title":"IPI-549, Selective PI3Kγ","description":"\u003cp\u003eIPI-549 is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays. Macrophage PI3K-γ has been found to be a critical switch between immune stimulation and suppression. IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K-γ inhibition via IPI-549. IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines. IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410904293716,"sku":"ABM147191-1","price":286.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410904326484,"sku":"ABM147191-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4827.png?v=1791103604","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-ipi-549-selective-pi3k","provider":"ABMIUM","version":"1.0","type":"link"}