{"product_id":"tribio-ionomycin-calcium-ca2-ionophore","title":"Ionomycin Calcium, Ca2+ ionophore","description":"\u003cp\u003eFermentation Product: from Streptomyces conglobatus\u003c\/p\u003e\n\u003cp\u003eHighly selective nonfluorescent calcium (Ca 2+ ) ionophore. In human neutrophils it induces a rapid rise in cytosolic Ca 2+ which is due to both release from cytosolic Ca 2+ stores as well as Ca 2+ influx. It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase. Down regulates beta-catenin\/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site. In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK\/JNK and HSF\/HSE interaction leading to upregulation of HSP70 biosynthesis\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"1 MG","offer_id":57410919465300,"sku":"ABM147186-1","price":62.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410919498068,"sku":"ABM147186-2","price":193.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2078-1.jpg?v=1791830453","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-ionomycin-calcium-ca2-ionophore","provider":"ABMIUM","version":"1.0","type":"link"}