{"product_id":"tribio-icrt5-b-catenin-inhibitor","title":"iCRT5, b-catenin inhibitor","description":"\u003cp\u003eA selective CRT (β-catenin-responsive transcription) inhibitor. IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction. Displays poor inhibition of cell proliferation in triple-negative breast cancer cells. Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs. Modulators of Wnt signaling show great promise in animal models of several cancers. Cell permeable\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410911699284,"sku":"ABM147163-1","price":372.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410911732052,"sku":"ABM147163-2","price":94.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1371.png?v=1791103621","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-icrt5-b-catenin-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}