{"product_id":"tribio-iberdomide-cereblon-modulator-molecular-glue","title":"Iberdomide, Cereblon modulator\/Molecular glue","description":"\u003cp\u003eModulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC 50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC 50 = 1 nM)) and Aiolos (IKZF3; EC 50 = 0.5 nM). It is more specific for the cereblon complex and does not degrade GSPT1 of CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells. Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE). It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410908324180,"sku":"ABM147153-1","price":454.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410908356948,"sku":"ABM147153-2","price":136.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3921.png?v=1791103613","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-iberdomide-cereblon-modulator-molecular-glue","provider":"ABMIUM","version":"1.0","type":"link"}