{"product_id":"tribio-halofuginone-hbr-prolyl-trna-synthase-inhibitor","title":"Halofuginone HBr, Prolyl-tRNA synthase inhibitor","description":"\u003cp\u003ePotent and selective glutamyl-prolyl-tRNA synthetase inhibitor (Ki=18.3 nM) derived from the natural product febrifugine. Exhibits little toxicity at concentrations (\u0026lt;10 µM) that reduce TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation. Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein and phosphorylation levels. Blocks fibrosis, angiogenesis, and tumor progression, as well as differentiation of TH17 immune cells. Simultaneously activates the Integrated Stress Response (ISR) and mTOR signaling in mouse embryo fibroblasts\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410916811092,"sku":"ABM147126-1","price":65.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410916843860,"sku":"ABM147126-2","price":107.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2381.png?v=1791103632","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-halofuginone-hbr-prolyl-trna-synthase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}