{"product_id":"tribio-gsk3326595-selective-prmt5-inhibitor","title":"GSK3326595, Selective PRMT5 inhibitor","description":"\u003cp\u003eGSK3326595 is a potent (IC50 = 6.2nM), selective (\u0026gt;4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5. PRMT5 inhibition activated the p53 pathway via induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both in vitro and in vivo. Combination therapy with palbociclib (CDK4\/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis. Currently in clinical Trials\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410909372756,"sku":"ABM147105-1","price":319.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410909405524,"sku":"ABM147105-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4028.png?v=1791103615","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-gsk3326595-selective-prmt5-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}