{"product_id":"tribio-grapiprant-ep4-receptor-antagonist","title":"Grapiprant, EP4 receptor antagonist","description":"\u003cp\u003eGrapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist. It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis. EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression. Grapiprant\/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410919104852,"sku":"ABM147084-1","price":482.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410919137620,"sku":"ABM147084-2","price":139.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4006.png?v=1791103638","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-grapiprant-ep4-receptor-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}