{"product_id":"tribio-ganetespib-hsp90-inhibitor","title":"Ganetespib, HSP90 Inhibitor","description":"\u003cp\u003eGanetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site. It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50’s between 14 and 280 nM. Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes. In multiple clinical trials for various cancers\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410911174996,"sku":"ABM147061-1","price":409.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410911207764,"sku":"ABM147061-2","price":106.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4474.png?v=1791103619","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-ganetespib-hsp90-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}