{"product_id":"tribio-enasidenib-mutant-isocitrate-dehydrogenase-2-idh2-inhibitor","title":"Enasidenib, Mutant isocitrate dehydrogenase 2 (IDH2) inhibitor","description":"\u003cp\u003eEnasidenib is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q\/WT heterodimer and 10 nM IDH2R172K\/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2). It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells. Recently approved for clinical use by the FDA\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410897346900,"sku":"ABM146980-1","price":368.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410897379668,"sku":"ABM146980-2","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4660.png?v=1791103438","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-enasidenib-mutant-isocitrate-dehydrogenase-2-idh2-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}