{"product_id":"tribio-ccg-4986-rgs4-inhibitor","title":"CCG-4986, RGS4 inhibitor","description":"\u003cp\u003eThe first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4. It covalently modifies RGS4 by inhibiting its interaction with Gα (IC50 = 3-5 µM) and suppressing GTPase activity. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling. A novel tool for exploring the involvement of RGS4 in physiological processes\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410885157204,"sku":"ABM146796-1","price":432.0,"currency_code":"USD","in_stock":true},{"title":"5 MG","offer_id":57410885189972,"sku":"ABM146796-2","price":118.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1431.png?v=1791103408","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-ccg-4986-rgs4-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}