{"product_id":"tribio-boceprevir-antiviral-sars-cov-2-mpro-inhibitor","title":"Boceprevir, Antiviral; SARS-CoV-2 Mpro inhibitor","description":"\u003cp\u003eBoceprevir directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM; initial inhibition constant Ki = 7.8 µM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response. Recently, it was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 µM) and in cells (EC50 = 1.9 µM, virus-induced cytopathic effects (CPE)\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410870247764,"sku":"ABM146735-1","price":409.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410870280532,"sku":"ABM146735-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5087.png?v=1791103246","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-boceprevir-antiviral-sars-cov-2-mpro-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}