{"product_id":"tribio-bix-01294-histone-methyl-transferase-inhibitor","title":"BIX-01294, Histone methyl transferase inhibitor","description":"\u003cp\u003eBIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 µM) as well as GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro. BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410865135956,"sku":"ABM146718-1","price":392.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410865168724,"sku":"ABM146718-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1335.png?v=1791103230","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-bix-01294-histone-methyl-transferase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}