{"product_id":"tribio-badge-pparg-antagonist","title":"BADGE, PPARg antagonist","description":"\u003cp\u003ePPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model. Induces apoptosis via PPARγ-independent mechanisms. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism. Increases osteoblastogenesis and bone mass in a mouse model. Active in vivo\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410861695316,"sku":"ABM146668-1","price":49.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410861728084,"sku":"ABM146668-2","price":163.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2618.png?v=1791103222","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-badge-pparg-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}