{"product_id":"tribio-alectinib-alk-inhibitor-potent","title":"Alectinib, ALK inhibitor, potent","description":"\u003cp\u003ePotent inhibitor of wild-type and fusion ALK (IC50 = 1.9 nM) and RET (IC50 = 4.8 nM), but not ROS1 tyrosine kinase activity. Significantly reduces proliferation and induces apoptosis in NSCLC, however these tumors can become resistant by activating Yes-associated protein 1 (YAP1). Causes cell death in glioblastoma cells via inhibition of STAT3, and prolongs the survival of mice harboring intracerebral GBM xenografts. Has been used to enable allogeneic stem cell transplantation in a patient with ALK-positive anaplastic large-cell lymphoma. Clinically useful anticancer agent\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410869657940,"sku":"ABM146589-1","price":335.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410869690708,"sku":"ABM146589-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4793.png?v=1791103243","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-alectinib-alk-inhibitor-potent","provider":"ABMIUM","version":"1.0","type":"link"}