{"product_id":"tribio-ai-1-nrf2-activator","title":"AI-1, Nrf2 activator","description":"\u003cp\u003eA novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology. Cell permeable\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410868478292,"sku":"ABM146584-1","price":458.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410868511060,"sku":"ABM146584-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1471.png?v=1791103238","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-ai-1-nrf2-activator","provider":"ABMIUM","version":"1.0","type":"link"}