{"product_id":"tribio-abemaciclib-cdk-4-6-inhibitor","title":"Abemaciclib, CDK 4\/6 inhibitor","description":"\u003cp\u003ePotent and selective CDK4\/6 inhibitor (IC50 = 2 nM and 10 nM respectively). Induces G1 cell cycle arrest in colo-205 colorectal cells, MDA-MB-361 breast cancer cells, and MV4-11 AML cells; also active in several human tumor xenograft models. Displays efficacy in patients with various solid tumors including breast cancer, non-small cell lung cancer, glioblastoma, melanoma, colorectal cancer, and hormone receptor-positive breast cancer. Abemaciclib induced a T cell inflamed tumor microenvironment and enhanced the efficacy of PD-L1 checkpoint blockade in MCF-7 breast cancer cells. FDA approved for the treatment of advanced breast cancers\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410859008340,"sku":"ABM146557-1","price":188.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410859041108,"sku":"ABM146557-2","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4833.png?v=1791103217","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-abemaciclib-cdk-4-6-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}