{"product_id":"tribio-a-769662-ampk-activator","title":"A-769662, AMPK activator","description":"\u003cp\u003eA potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the β and γ subunits and not the AMP binding site. EC50=0.8 µM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 µM. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob\/ob mice2. Inhibits adipocyte differentiation. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming. Synergizes with AICAR5. Cell permeable\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410853863764,"sku":"ABM146548-1","price":409.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410853896532,"sku":"ABM146548-2","price":118.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1171.png?v=1791103210","url":"https:\/\/www.abmium.com\/fr\/products\/tribio-a-769662-ampk-activator","provider":"ABMIUM","version":"1.0","type":"link"}