{"product_id":"reed-biotech-tle1-2-3-4-polyclonal-antibody-ra30517","title":"TLE1\/2\/3\/4 Polyclonal Antibody","description":"\u003cp\u003efunction:Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.,PTM:Phosphorylated, probably by CDC2. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2\/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.,similarity:Belongs to the WD repeat Groucho\/TLE family.,similarity:Contains 6 WD repeats.,subcellular location:Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif).,tissue specificity:In all tissues examined, mostly in brain, liver and muscle.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250480554324,"sku":"ABM5034911-1","price":137.0,"currency_code":"USD","in_stock":true},{"title":"100 µL","offer_id":57250480587092,"sku":"ABM5034911-2","price":184.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_7ee2acbc-1ff3-4098-9fce-a34537cbba62.webp?v=1790235368","url":"https:\/\/www.abmium.com\/fr\/products\/reed-biotech-tle1-2-3-4-polyclonal-antibody-ra30517","provider":"ABMIUM","version":"1.0","type":"link"}