{"product_id":"reed-biotech-rfx5-rabbit-polyclonal-antibody-ra29374","title":"RFX5 Rabbit Polyclonal Antibody","description":"\u003cp\u003eA lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251136438612,"sku":"ABM5033768-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251136471380,"sku":"ABM5033768-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_18aa232b-8585-4d20-ba66-4670d923ab28.webp?v=1790235047","url":"https:\/\/www.abmium.com\/fr\/products\/reed-biotech-rfx5-rabbit-polyclonal-antibody-ra29374","provider":"ABMIUM","version":"1.0","type":"link"}