{"product_id":"reed-biotech-pen2-rabbit-polyclonal-antibody-ra28669","title":"PEN2 Rabbit Polyclonal Antibody","description":"\u003cp\u003ePresenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer\u0026amp;apos;s disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250465284436,"sku":"ABM5033063-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250465317204,"sku":"ABM5033063-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_265994d2-3945-4aa2-97a3-5a3f5547c2fb.webp?v=1790234866","url":"https:\/\/www.abmium.com\/fr\/products\/reed-biotech-pen2-rabbit-polyclonal-antibody-ra28669","provider":"ABMIUM","version":"1.0","type":"link"}