{"product_id":"reed-biotech-p53rfp-polyclonal-antibody-ra28418","title":"p53RFP Polyclonal Antibody","description":"\u003cp\u003ecaution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.,domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53\/p53-dependent but caspase-independent mechanism.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated.,similarity:Belongs to the RBR family. RNF144 subfamily.,similarity:Contains 1 IBR-type zinc finger.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with UBE2L3, UBE2L6 and LCMT2.,tissue specificity:Broadly expressed, with lowest levels in brain, spleen and thymus.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250566046036,"sku":"ABM5032812-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250566078804,"sku":"ABM5032812-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_6c75acb9-d94a-49c4-916a-d76411c09246.webp?v=1790234802","url":"https:\/\/www.abmium.com\/fr\/products\/reed-biotech-p53rfp-polyclonal-antibody-ra28418","provider":"ABMIUM","version":"1.0","type":"link"}