{"product_id":"reed-biotech-nfkappab-p105-p50-polyclonal-antibody-ra27788","title":"NFκB-p105\/p50 Polyclonal Antibody","description":"\u003cp\u003enuclear factor kappa B subunit 1(NFKB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250268184916,"sku":"ABM5032182-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250268217684,"sku":"ABM5032182-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_3239c1c0-5c11-418f-be26-4351d3878fbb.webp?v=1790234621","url":"https:\/\/www.abmium.com\/fr\/products\/reed-biotech-nfkappab-p105-p50-polyclonal-antibody-ra27788","provider":"ABMIUM","version":"1.0","type":"link"}