{"product_id":"reed-biotech-glur-2-polyclonal-antibody-ra25354","title":"GluR-2 Polyclonal Antibody","description":"\u003cp\u003eglutamate ionotropic receptor AMPA type subunit 2(GRIA2) Homo sapiens Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-\u0026amp;gt;CGG; Q-\u0026amp;gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q\/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251087024468,"sku":"ABM5029748-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251087057236,"sku":"ABM5029748-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/fr\/products\/reed-biotech-glur-2-polyclonal-antibody-ra25354","provider":"ABMIUM","version":"1.0","type":"link"}