{"product_id":"rabbit-polyclonal-antibody-to-sppl3-n-term-p30143","title":"Anti-SPPL3 (N-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003eIntramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. SPPL3 acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1. catalyses the intramembrane cleavage of the envelope glycoprotein gp130 and\/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031227306324,"sku":"ABM413450-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031227339092,"sku":"ABM413450-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031227371860,"sku":"ABM413450-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-sppl3-n-term-p30143","provider":"ABMIUM","version":"1.0","type":"link"}