{"product_id":"rabbit-polyclonal-antibody-to-rnf8-ab-137-p41604","title":"Anti-RNF8 (Ab-137) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRNF8\u003c\/strong\u003e is an E3 ubiquitin-protein ligase that plays a key role in DNA damage signalling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyses the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58162488443220,"sku":"ABM418768-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58162488475988,"sku":"ABM418768-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58162488508756,"sku":"ABM418768-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-rnf8-ab-137-p41604","provider":"ABMIUM","version":"1.0","type":"link"}