{"product_id":"rabbit-polyclonal-antibody-to-plekhm1-n-term-p31210","title":"Anti-PLEKHM1 (N-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003ePLEKHM1\u003c\/strong\u003e acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. PLEKHM1 acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. PLEKHM1 is required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031445442900,"sku":"ABM414418-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031445475668,"sku":"ABM414418-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031445508436,"sku":"ABM414418-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-plekhm1-n-term-p31210","provider":"ABMIUM","version":"1.0","type":"link"}