{"product_id":"rabbit-polyclonal-antibody-to-nedd4l-phospho-ser448-p44229","title":"Anti-NEDD4L (phospho-Ser448) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eNEDD4L\u003c\/strong\u003e is an E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signalling pathways including autophagy, innate immunity or DNA repair. NEDD4L inhibits TGF-beta signalling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Down-regulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58167944479060,"sku":"ABM420836-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58167944511828,"sku":"ABM420836-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58167944544596,"sku":"ABM420836-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-nedd4l-phospho-ser448-p44229","provider":"ABMIUM","version":"1.0","type":"link"}