{"product_id":"rabbit-polyclonal-antibody-to-lgr5-gpr49-p30269","title":"Anti-LGR5 (GPR49) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eLGR5\u003c\/strong\u003e is a receptor for R-spondins that potentiates the canonical Wnt signalling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signalling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031238021460,"sku":"ABM413535-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031238054228,"sku":"ABM413535-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031238086996,"sku":"ABM413535-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-lgr5-gpr49-p30269","provider":"ABMIUM","version":"1.0","type":"link"}