{"product_id":"rabbit-polyclonal-antibody-to-lats1-p23426","title":"Anti-LATS1 Rabbit Polyclonal Antibody","description":"\u003cp\u003eNegative regulator of YAP1 in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3\/MST2 and STK4\/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1\/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1\/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031162098004,"sku":"ABM413145-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031162130772,"sku":"ABM413145-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031162163540,"sku":"ABM413145-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-lats1-p23426","provider":"ABMIUM","version":"1.0","type":"link"}