{"product_id":"rabbit-polyclonal-antibody-to-foxo3-n-term-p33903","title":"Anti-FOXO3 (N-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eFOXO3\u003c\/strong\u003e is a transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. FOXO3 acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins. Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58157201752404,"sku":"ABM416764-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58157201785172,"sku":"ABM416764-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58157201817940,"sku":"ABM416764-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/fr\/products\/rabbit-polyclonal-antibody-to-foxo3-n-term-p33903","provider":"ABMIUM","version":"1.0","type":"link"}