{"product_id":"proteogenix-cd279-recombinant-protein","title":"CD279 Recombinant Protein","description":"\u003ch2\u003eGeneral information on CD279 Recombinant Protein:\u003c\/h2\u003e \u003cp\u003e CD279 (programmed cell death protein 1; PD-1) is a type I transmembrane protein that belongs to the CD28 \/ CTLA-4 family of immune receptors, which mediates signals that regulate immune responses. Members of the CD28 \/ CTLA-4 family have been shown to promote T cell activation (CD28 and ICOS) or deactivate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, bone marrow cells, and some thymocytes. In vitro, CD279 binding can prevent TCR-mediated T cell proliferation and the production of IL-1, IL-4, IL-10, and IFN-γ. Furthermore, the binding of CD279 can also prevent BCR signaling. CD279-deficient mice have defective peripheral tolerance and spontaneously develop autoimmune diseases.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number PX-P4117. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Mammalian cells; Expression system: Eukaryotic expression; Purity: \u0026gt;90% by SDS-PAGE; Molecular weight: 40kDa; Tag: C-terminal His Tag; Fragment: Met1~Val170; Buffer: PBS pH7.5; Applications: ELISA, WB.\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/PX-P4117.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57376170967380,"sku":"ABM146388-1","price":247.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57376171000148,"sku":"ABM146388-2","price":367.2,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57376171032916,"sku":"ABM146388-3","price":927.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/bioactivity-validation-cd279-recombinant-protein.jpg?v=1790896525","url":"https:\/\/www.abmium.com\/fr\/products\/proteogenix-cd279-recombinant-protein","provider":"ABMIUM","version":"1.0","type":"link"}