{"product_id":"proteogenix-anti-phox2b-polyclonal-antibody","title":"Anti-PHOX2B Polyclonal Antibody","description":"\u003cp\u003eAnti-PHOX2B Polyclonal Antibody: A Powerful Tool for Studying Neural Development and Disorders\u003c\/p\u003e \u003ch2\u003eIntroduction:\u003c\/h2\u003e \u003cp\u003eThe Anti-PHOX2B Polyclonal Antibody is a highly specific and sensitive tool for studying the role of PHOX2B in neural development and disorders. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the human PHOX2B protein sequence. It has been extensively validated for use in various applications, making it a reliable choice for researchers in the field of biotechnology.\u003c\/p\u003e \u003ch2\u003eBiological Function:\u003c\/h2\u003e \u003cp\u003ePHOX2B is a transcription factor that plays a critical role in the development of the autonomic nervous system. It is involved in the differentiation and maturation of neurons and controls the expression of genes involved in autonomic functions such as breathing, heart rate, and digestion. Mutations in the PHOX2B gene have been linked to various neural disorders, including congenital central hypoventilation syndrome and neuroblastoma.\u003c\/p\u003e \u003ch2\u003eMain Applications:\u003c\/h2\u003e \u003cp\u003eThe Anti-PHOX2B Polyclonal Antibody is primarily used in immunohistochemistry (IHC) and Western blotting (WB) techniques to detect the expression of PHOX2B in tissue samples. It has also been successfully used in chromatin immunoprecipitation (ChIP) assays to study the binding of PHOX2B to specific DNA sequences. Moreover, this antibody has been used in fluorescence-activated cell sorting (FACS) analysis to isolate PHOX2B-expressing cells from complex tissue samples.\u003c\/p\u003e \u003ch2\u003eExperimental Use Cases:\u003c\/h2\u003e \u003cp\u003eThe Anti-PHOX2B Polyclonal Antibody has been used in various experimental studies to investigate the role of PHOX2B in neural development and disorders. For example, researchers have used this antibody to study the expression of PHOX2B in neuroblastoma cell lines and primary tumors, providing valuable insights into the pathogenesis of this aggressive childhood cancer. Additionally, this antibody has been used to identify PHOX2B-expressing neurons in the brainstem, helping to unravel the complex neural circuits involved in autonomic functions.\u003c\/p\u003e \u003cp\u003eConclusion:\u003cbr\u003e In summary, the Anti-PHOX2B Polyclonal Antibody is a highly specific and sensitive tool for studying the role of PHOX2B in neural development and disorders. Its reliable performance in various applications and extensive validation make it a valuable asset for researchers in the biotechnology field. Whether you are studying neural development, neurodegenerative diseases, or cancer, this antibody will provide you with accurate and reproducible results, helping you advance your research and contribute to the understanding of complex biological processes.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-A22060. For research use only.\u003c\/p\u003e\u003cp\u003eTarget: Paired mesoderm homeobox protein 2B; Neuroblastoma Phox; NBPhox; PHOX2B homeodomain protein; Paired-like homeobox 2B; PHOX2B; PMX2B; Clonality: Polyclonal Antibody; Applications: IHC, ELISA.\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-A22060.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57353757131092,"sku":"ABM121707-1","price":143.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57353757163860,"sku":"ABM121707-2","price":231.2,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57353757196628,"sku":"ABM121707-3","price":716.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Primaryantibodies-CCt9H6Tc_c68aca62-b024-4cb1-a85d-0ce731aeefda.svg?v=1790886052","url":"https:\/\/www.abmium.com\/fr\/products\/proteogenix-anti-phox2b-polyclonal-antibody","provider":"ABMIUM","version":"1.0","type":"link"}